About Anal Fissure

What Causes Anal Fissure Pain?


An anal fissure is a tear in the lining of the anus. The tear typically extends into a circular ring of muscle called the internal anal sphincter.

Once a fissure develops, the internal anal sphincter typically goes into spasm, causing further separation of the tear and causing severe pain. These symptoms can occur after every bowel movement and last several minutes to hours. Keeping the anal sphincter muscle relaxed to prevent spasm is critical to break this vicious cycle.



Intra-Anal Application is Critical


Topical Nifedipine or Diltiazem work by reducing the internal anal sphincter pressure. They are most effective when applied intra-anally where they are absorbed by the tissue surrounding the internal anal sphincter muscle (anoderm)1. Topical treatment with these medications three times a day is critical to keep the sphincter muscle relaxed. Depending on the severity of the spasm it may take anywhere from a day to several weeks for the sphincter muscle to relax.

DoseRite Makes Application Easy


DoseRite helps patients accurately apply anal fissure medication within the anal canal to keep the anal sphincter muscle relaxed and eliminate pain.

DoseRite’s patented applicator provides a simple and painless way to accurately apply your medication within the anal canal. The applicator’s side slotted design ensures medication is applied directly to the anoderm for maximum absorption by the internal sphincter muscle.


Learn More About DoseRite

  1. Torrabadella L, Salgado G. Controlled Dose Delivery in Topical Treatment of Anal Fissure: Pilot Study of a New Paradigm. Dis Colon Rectum 2005; 49: 865–868