Frequently Asked Questions

An empty dosing jar
A purple adaptor for your medication tube. If you’re using the DoseRite jar you can discard the purple medication tube adapter.
Syringes for creating a single dose of your medication.
Applicators for delivery of medication into the anal canal.
Cleaning tool to maintain a clear medication channel in the syringes and applicators
Wooden spatula for transferring medication
Patient Information Guide
No, DoseRite works in combination with the Anal Fissure medication prescribed by your Physician.
Consult your physician or pharmacist for dosing and administration instructions that are right for you.
Most physicians recommend the following:
Calcium Channel Blocker (e.g. Diltiazem, Nifedipine) = 0.5ml per dose (3 doses per day)
Nitroglycerine (e.g. Rectiv) = 0.3ml per dose (2 doses per day)

Yes, the DoseRite’s new reusable pack includes applicators that can be washed and reused. Please see Directions for Use for important cleaning instructions.

No, the slim design of DoseRite’s applicator is thinner and more comfortable than using a finger to medicate. The applicator is made from a smooth plastic and lubrication can be used to ease the tip into the body if needed. A lubricant such as Aquaphor can be used as a lubricant.
No, DoseRite is available without a prescription. However, you will need a prescription for the medication that is used with DoseRite. Most patients are prescribed Diltiazem, Nifedipine or Nitroglycerine (Rectiv) to treat their anal fissure. DoseRite works in combination with any of these medications.
DoseRite is simply a dosing and applicator system. It can work with other medications that are safe to apply within the anal canal, however it is designed for use with medications that relax the anal sphincter muscle, such as Diltiazem, Nifedipine or Nitroglycerine (Rectiv).
The applicator is made from a medical-grade plastic.
No, DoseRite is 100% latex free.
DoseRite is available through or through participating compounding pharmacies. Send us an email to find a participating compound pharmacy near you.
You will need to check with your insurance policy. Most policies do not cover DoseRite.
We recommend that your physician prescribe 50-grams of medication for a 4-week treatment regimen (three applications per day).
DoseRite is available in the U.S., Europe and Australia. We are working to make DoseRite available worldwide.
An anal fissure is a small tear in the anal canal lining that causes pain and bleeding, often occurring during bowel movements. Fissures are common in the general population, but are often confused with other anal conditions, such as hemorrhoids.
Anal Fissures typical cause sharp pain during a bowel movement that may last from several minutes to a few hours. You may also notice bright red blood with bowel movements. Some people with anal fissures may have little to no pain between bowel movements. Many people with an anal fissure are fearful of having a bowel movement and may try to avoid it because of the pain.
Fissures are usually caused by trauma to the inner lining of the anus from a bowel movement or other stretching of the anal canal. A hard, dry bowel movement is typically responsible, but loose stools and diarrhea can also cause fissures. Treatments of anal fissures are aimed at softening stools and relaxing the anal sphincter muscle to reduce pain and promote healing.
Medications may be prescribed to allow for relaxation of the anal sphincter muscles (e.g. Nifedipine, Diltiazem). These are typically creams that require a specialized (compounding) pharmacy to make. Rectiv, an NTG, can also be prescribed by a physician.
The only way to stop fissure pain is to relax the internal sphincter muscles. Most fissure pain is caused when the anal sphincter spasms during a bowel movement. Fissure medications such as Diltiazem, Nifedipine and Nitroglycerine creams are designed to relax the sphincter muscle. When the sphincter muscle relaxes, the fissure pain goes away.
DoseRite provides a consistent, pain-free method of applying medication within the anal canal. When medication is delivered consistently within the anal canal the internal anal sphincter muscle will stay relaxed and anal fissure pain will subside. Reducing anal fissure pain will allow you to resume your daily life while your fissure heals, usually in about 4-weeks.
DoseRite helps to relax the anal sphincter muscles allowing the fissure to heal over time. We recommend a 4-week treatment regimen with the medication prescribed by your physician.
Yes, this is the way most medications are indicated for use. Medication delivered directly to the anal mucosa surrounding the anal sphincter muscle is more likely to be absorbed effectively and lead to greater sphincter relaxation.